gRNA Process Development Scientist

Job Description

We are seeking a process development scientist to join the guide-RNA (gRNA) process development team. The successful candidate will be contributing to gRNA drug substance process development for programs in clinical development. In this role, the candidate will synthesize, purify, and characterize gRNAs in an effort to develop drug substance manufacturing processes and controls.

• Execute solid-phase synthesis and purification experiments to support process development, scale-up, and transfer of oligonucleotide drug substance manufacturing.
• Execute routine analytics including HPLC and UV-Vis.
• Prepare buffers, reagents, and stock solutions used for process development activities, following established recipes and SOPs.
• Compile and present data to team members and key stakeholders
• Maintain an updated lab notebook, order materials, maintain lab equipment, and support equipment troubleshooting as needed.
• Uphold lab safety to the highest level of standards.