Scientist II

Posted by Sigma Inc

Ridgefield, MA

Permanent

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Scientist II Image Analysis & Digital Pathology (2D/3D Imaging)

Ridgefield, CT (Onsite)
Contract: 24 Months
Company: Sigma Inc

Job Summary

Sigma Inc is seeking a highly skilled Scientist II Image Analysis & Digital Pathology to join our team in Ridgefield, CT. This role focuses on developing advanced image analysis pipelines for biomedical research, including histology and multiplex imaging.

If you have experience with machine learning, digital pathology, and biomedical image analysis, this is an excellent opportunity to work in a collaborative, cutting-edge research environment.

Key Responsibilities

Develop and optimize image analysis pipelines for both 2D and 3D biomedical images
Perform quantitative analysis of:
- Histology
- IHC (Immunohistochemistry)
- IF (Immunofluorescence)
- Multiplex imaging datasets
Apply machine learning and classical image processing techniques for:
- Feature extraction
- Segmentation
- Classification
Integrate and utilize image analysis platforms such as:
- HALO
- Visiopharm
- QuPath
- CellProfiler
Collaborate with pathologists, biologists, and data scientists to define analytical endpoints
Validate image-derived biomarkers and ensure scientific rigor
Document workflows and ensure reproducibility and compliance
Support data visualization and reporting for scientific insights
Enable cross-lab collaboration through algorithm and image transfer

Required Qualifications

Bachelors degree with 3+ years of experience, OR
Masters degree in a related scientific discipline (or equivalent experience)
Strong programming skills in:
- Python
- R
Proven experience applying machine learning techniques in biomedical or pathology imaging
Experience in:
- Cell image analysis
- Marker quantification
- Multiplex IHC / digital pathology
Hands-on experience with tools such as:
- HALO AI
- Visiopharm
- QuPath
- CellProfiler
Strong analytical, problem-solving, and independent thinking skills